METHOD OF ESTIMATION OF PATIENT'S MENTAL CONDITION WITH ENDOGENIC MENTAL DISORDERS AT THEIR CLINICAL EXAMINATION AND METHOD OF COMPLEX EVALUATION OF THE STATE OF THE IMMUNE SYSTEM OF SUCH PATIENTS Russian patent published in 2018 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to psychiatry, and can be used to monitor the condition of patients with endogenous psychoses, as well as to assess the severity of the mental state. A method for assessing the mental state of patients with endogenous mental disorders includes clinical observation and psychometric examination. Additionally, a complex assessment of the state of the immune system, in this case, the enzymatic activity of leukocyte elastase (LE), functional activity α₁-Proteinase inhibitor (α₁-PI) and the level of autoantibodies to neuroantigens - the main protein of myelin (MPM) and the protein S100B. Evaluation of the mental state of patients is carried out by comparing the degree of deviation of the determined immunological parameters of blood serum from the similar indicators of serum samples of healthy individuals. Group of inventions also refers to assessing the state of the immune system of patients with endogenous psychiatric disorders. Range of activity of leukocyte elastase (LE) - (201-250) nmol/min × ml is characterized as a slight increase, range - (251-300) nmol/min × ml - a moderate increase, and an increase in activity (LE) of more than 300 nmol/min × ml - marked increase in normal PE activity in human serum - (150-200) nmol/min × ml. Reduced or normal activity α₁-proteinase inhibitor (α₁-PI) with increased LE activity testifies to insufficiency of antiproteolytic activity of blood serum under normal activity α1-PI - (28-32) IE/ml; and an increase in the level of autoantibodies (aAT) to the main myelin protein (MPM) and protein S100B, at a rate of (0.6-0.9) units. opt. pl. characterizes the presence of an autoimmune component of the pathological process in the brain.

EFFECT: use of this group of inventions makes it possible to carry out a comprehensive assessment of the mental state of patients with endogenous mental disorders, taking into account the pathological process in the brain at a certain time interval of the development of the disease, reflecting the degree of activity (severity) of the psychotic state.

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