METHOD FOR PREDICTION OF FUNCTIONAL RECOVERY OF PATIENTS WITH ISCHEMIC STROKE Russian patent published in 2019 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely neurology, and enables predicting functional recovery of patients with ischemic stroke. That is ensured by a clinical neurological examination and a level of activation of the patient's immune system. On the first day of the acute period of the disease by measuring a patient's blood plasma enzymatic activity of leukocyte elastase (LE), functional activity α1-proteinase inhibitor (α1-PI), level of autoantibodies (AB) to neurotrophin S100b and myelin basic protein (MBP) and determining functional recovery probability in accordance with formula

where p is functional recovery probability; e is the base of the natural logarithm, 10.9 is the regression constant, 0.03 is the coefficient with the enzymatic activity index LE, 0.17 is coefficient of functional activity index α1-PI, 9.1 – coefficient with the level of autoantibodies to neurotrophin S100b AB, 7.4 – coefficient with the level of autoantibodies to the main protein of myelin MBP. Result of measuring enzymatic activity LE are expressed in units [nmol/min×ml]. Functional activity measurement result α1-PI expressed in units of [IU/ml]. Result of measuring the level of autoantibodies AB to neuroantigens is expressed in units of optical density (units OP). If p≥0.50, then functional recovery is possible, and with p<0.50 – functional recovery of the patient is unlikely.

EFFECT: invention has high sensitivity (77,8 %) and specificity (83,3 %) of predicting the possibility of functional recovery in the acute period of ischemic stroke.

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