GPR40 RECEPTOR AGONIST, METHODS OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT Russian patent published in 2018 - IPC C07D209/12 C07D209/14 C07D209/30 C07D231/56 C07D235/12 C07D235/26 C07D249/18 C07D261/20 C07D401/06 C07D403/06 C07D405/06 C07D405/12 C07D405/14 C07D409/04 C07D413/12 C07D413/14 C07D417/06 C07D471/04 A61K31/404 A61K31/416 A61K31/4155 A61K31/4184 A61K31/422 A61K31/427 A61K31/437 A61K31/4439 A61K31/497 A61K31/506 A61K31/5377 A61P3/10 

Abstract RU 2650506 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a novel compound of formula (I) or a pharmaceutically acceptable salt or isomer thereof. In the compound of formula (I), X is C or N, Y is C, N, C = O or C-halogen, Z is C or N, Q is O or NH, W is C, N, C1-C6 alkyl or C-halogen, and the remaining symbols and radicals are as defined in the claims. Compound of formula (I) has GPR40 receptor agonist activity, enhances insulin secretion and inhibits blood sugar rise after glucose loading. Invention also relates to a pharmaceutical composition containing said compound as an active ingredient.

EFFECT: compound is suitable for treating diabetes and its complications.

10 cl, 1 tbl, 232 ex

формула (I) - formula (I)

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RU 2 650 506 C2

Authors

Li Sung Bae

Paek Seung Jup

Joon Sook Kiung

Joon Seung Khiun

Choj Dzeung Soon

Dates

2018-04-16Published

2013-11-08Filed