FIELD: pharmaceutical chemistry.
SUBSTANCE: group of inventions relates to a compound of formula 1, its pharmaceutically acceptable salt, a stereoisomer and a pharmaceutical composition based on it. In formula 1, R1 is selected from hydrogen, alkyl having 1 to 6 carbon atoms, or cycloalkyl having 3 to 6 carbon atoms, where alkyl may be substituted by cycloalkyl having 3 to 6 carbon atoms; R2 is selected from hydrogen, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, halogen, or CF3 where alkyl may be substituted by cycloalkyl having 3 to 6 carbon atoms, or at least one halogen; R3, R4, R5A and R5B are presented in the claims.
EFFECT: compound of formula 1 as an agonist of sphingosine-1-phosphate (S1P) receptors.
9 cl, 22 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS, METHODS OF PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE AGENT | 2014 |
|
RU2654483C2 |
| PHARMACEUTICAL COMPOUNDS | 2005 |
|
RU2422449C2 |
| GPR40 RECEPTOR AGONIST, METHODS OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT | 2013 |
|
RU2650506C2 |
| DERIVATIVES OF 1-(4-BENZYLPIPERAZIN-1-YL)-3-PHENYLPROPENONE AND THEIR USE, PHARMACEUTICAL COMPOSITION AND METHOD INHIBITING CHEMOKINE RECEPTORS (CCR-1) | 2003 |
|
RU2347782C2 |
| GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE INGREDIENT | 2008 |
|
RU2450001C2 |
| BENZOXEPIN PI3 INHIBITORS AND METHODS FOR USING THEM | 2010 |
|
RU2557658C2 |
| N1/N2-LACTAM ACETYL-CoA-CARBOXYLASE INHIBITORS | 2011 |
|
RU2540337C2 |
| ARYLCARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | 2003 |
|
RU2340605C2 |
| SUBSTITUTED AZOL DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THESE DERIVATIVES, AND METHODS OF TREATING PARKINSON'S DISEASE WITH USING THESE DERIVATIVES | 2010 |
|
RU2578596C2 |
| BENZOXAZEPINE PI3 INHIBITORS AND METHODS OF USE | 2010 |
|
RU2654068C1 |
