NOVEL IMIDAZOLIDINE-2,4-DIONE DERIVATIVES Russian patent published in 2018 - IPC C07D403/06 C07D403/14 C07D417/06 C07D401/14 A61K31/4178 A61K31/4192 A61K31/4439 A61K31/433 A61P35/00 

Abstract RU 2650678 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically to a new imidazolidine-2,4-dione derivative of formula (I), where R1 is -CN, -SO2(C1-C6)alkyl, R2 is -CF3 or a halogen atom, R3 is (C1-C6)alkyl, X is CH or N, Y1 is a carbon atom, a sulfonyl or carbonyl group, Y2 is a carbon atom, a nitrogen atom, wherein the carbon atom may be optionally substituted with an -OH group, Y3 is a carbon atom, a nitrogen atom, Y4 is a carbon atom, a nitrogen atom, wherein the carbon atom and the nitrogen atom may be optionally substituted with one or more (C1-C6)alkyl group, R4 is H, halogen, -CN or -SO2(C1-C6)alkyl group, R5 is H, -CF3, (C1-C6)alkyl group or a halogen atom, each of independently represents a single bond or a double bond. Invention also relates to a pharmaceutical composition based on a compound of formula (I) and its use.

(I).

EFFECT: technical result is obtaining novel imidazolidine-2,4-dione derivatives useful in the treatment of cancer.

18 cl, 22 ex

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RU 2 650 678 C2

Authors

Oven Serzh

Lanko Kristof

Dyutryuel Oliver

Chao Tsi

Gu Kajchun

Dates

2018-04-17Published

2013-12-31Filed