METHOD OF PERSONIFIED PRESCRIBING OF TARGETED THERAPY AGENTS IN PATIENTS WITH METASTATIC KIDNEY CANCER IN PREOPERATIVE MODE Russian patent published in 2018 - IPC G01N33/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology, and relates to the personified administration of targeted therapy agents in patients with metastatic kidney cancer in a preoperative regimen. To do this the activity of proteasomes, calpaines, the content of NF-kB-nuclear factor kB p50, HIF-1α - a factor activated by hypoxia, content of the vascular endothelial growth factor, its receptor, phospho-m-TOR, the MSKCC coefficient, the degree of gradation of the Furman cell differentiation, criterion T and on the basis of the obtained values calculate the discriminant functions Y1, Y2, Y3, Y4 by the formulas. At Y1> Y2, the lack of effect on targeted therapy is predicted, and for Y1 <Y2 - effective targeted therapy is predicted. In case of Y1<Y2, the functions Y3 and Y4 are calculated: for Y3>Y4, targeted therapy with pazopanib is prescribed, and for Y3<Y4, targeted treatment with everolimus is prescribed.

EFFECT: method provides effective antitumor therapy due to individual approach to the choice of targeted therapy.

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