FIELD: chemistry.
SUBSTANCE: invention relates to a methanesulfonic acid salt and a base 3-(1,2,4-triazolo[4,3-a]pyridin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl) benzamide. Invention also relates to a crystalline salt of 3-(1,2,4-triazolo[4,3-a]pyridin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl) benzamide, to methods for preparing a crystalline salt, to a pharmaceutical composition having activity against Bcr-Abl kinase and its mutant forms, to a method for treating a cancerous disease.
EFFECT: technical result: obtaining a novel salt of methanesulfonic acid and base 3-(1,2,4-triazolo[4,3-a]pyridin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl) benzamide, characterised by high solubility in water, high inhibitory activity against Bcr-Abl kinase and its mutant forms and effective for the treatment of oncological diseases mediated by the activity of Bcr-Abl kinase and its mutant forms.
37 cl, 62 dwg, 14 tbl
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