FIELD: chemistry.
SUBSTANCE: invention relates to a novel sulphate of 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)benzamide, which can be used in treating diseases which respond to protein kinase inhibition. The sulphate is obtained by reacting 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)benzamide in form of a free base with sulphuric acid in a solvent medium.
EFFECT: salt has low hygroscopicity and high solubility.
2 cl, 8 dwg, 17 tbl, 11 ex
| Title |
Year |
Author |
Number |
| SALTS OF 4-METHYL-N-[3-(4-METHYLIMIDAZOLE-1-YL)-5-TRIFLUOROMETHYLPHENYL]-3-(4-PYRIDINE-3-YLPYRIMIDINE-2-YLAMINO)BENZAMIDE |
2013 |
- Manli Pol U.
- Shi Venchun
- Satton Pol Allen
- Karpinski Peter Kh.
- Vu Rain
- Monne Stefani
- Brotsio Jerg
|
RU2605551C2 |
| 4-METHYL-N-[3-(4-METHYLIMIDAZOL-1-YL)-5-TRIFLUOROMETHYLPHENYL]-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)BENZAMIDE SALTS |
2006 |
- Manli Pol U.
- Shi Vehn'Chun
- Satton Pol Allen
- Karpinski Petr Kh.
- Vu Rain
- Monn'E Stefani
- Brotsio Jerg
|
RU2483065C2 |
| 4-METHYL-[3-(4-METHYLIMIDAZOL-1-YL)-5-TRIFLUOROMETHYLPHENYL]-3-(4-PYRIDIN-3-YLPYRIMIDIN-2-YLAMINO)BENZAMIDE SALTS |
2006 |
- Manli Pol U.
- Shi Vehn'Chun
- Satton Pol Allen
- Karpinski Petr Kh.
- Vu Rain
- Monn'E Stefani
- Brotsio Jerg
|
RU2434864C2 |
| NOVEL CRYSTALLINE SALT FORM 3-(1,2,4-TRIAZOLO[4,3-A]PYRIDIN-3-YLETHYNYL)-4-METHYL-N-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-TRIFLUOROMETHYLPHENYL) BENZAMIDE FOR MEDICAL APPLICATION |
2016 |
- Chilov Germes Grigorevich
- Titov Ilya Yurevich
|
RU2652992C2 |
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2011 |
|
RU2612556C2 |
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2013 |
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- Mikhajlov Oleg Rostislavovich
- Uvarov Nikolaj Aleksandrovich
|
RU2551359C1 |
| METHOD OF PRODUCING N-[5-(3,5-DIFTORBENZIL)-1H-INDAZOLE-3-YL]-4-(4-METHYLPIPERAZINE-1-YL)-2-(TETRAHYDROPYRAN-4-YLAMINO)BENZAMIDE |
2013 |
- Barbudzhan Natale Alvaro
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| POLYMORPHIC MODIFICATIONS OF N-[(3-FLUORO-4-METHOXYPYRIDINE-2-YL)METHYL]-3-(METHOXYMETHYL)-1-({ 4-[(2-OXOPYRIDINE-1-YL)METHYL]PHENYL} METHYL)PYRAZOLE-4-CARBOXAMIDE AND THEIR SALTS |
2017 |
- Beaton, Haydn
- Crowe, David Malcolm
- Edwards, Hannah Joy
- Griffiths-Haynes, Nicholas James
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| NEW CRYSTALLINE MODIFICATION 2-(3, 5-BIS-TRIFLUOROMETHYLPHENYL)-H-[6-(1, 1-DIOXO-1 λ -THIOMORPHOLINE-4-YL)-4-(4-FLUORO-2-MEHTYLPHENYL)PIRIDINE-3-YL]-K-METHYLISOBUTYR AMIDE |
2004 |
- Khoffmann Torsten
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- Shvitter Urs
- Val'Dmajer Pius
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RU2330022C2 |
| COMPOUNDS AND COMPOSITIONS AS PROTEIN TYROSINE KINASE INHIBITORS |
2006 |
- Chzhan Guobao
- Rehn' Pinda
- Van Sja
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- Sim Taehbo
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RU2386630C2 |
