4-METHYL-N-[3-(4-METHYLIMIDAZOL-1-YL)-5-TRIFLUOROMETHYLPHENYL]-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)BENZAMIDE SALTS Russian patent published in 2013 - IPC C07D401/14 A61K31/506 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a new monophosphate salt of 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)benzamide which may be used for treating a disease responding to protein kinase activity inhibition. The method for preparing the monophosphate salt of 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)benzamide involves the reaction of 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)benzamide in the form of a free base with phosphoric acid in methanol. Also, the invention refers to a pharmaceutical composition containing: (a) a therapeutically effective amount of the monophosphate salt of 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)benzamide; and (b) at least one pharmaceutically acceptable carrier, a diluent, an excipient, as well as to the use of the therapeutically effective amount of the monophosphate salt of 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)benzamide in preparing a drug preparation for treating a disease responding to protein kinase activity inhibition.

EFFECT: preparing the composition for treating a disease responding to protein kinase activity inhibition.

4 cl, 8 dwg, 17 tbl, 11 ex