FIELD: chemistry.
SUBSTANCE: invention relates to compounds of general formula (I) or to pharmaceutically acceptable salts thereof. In general formula (I), R1 is lower alkyl, phenyl optionally substituted with one or more R1', cycloalkyl or pyridyl; each R1' is independently a lower alkyl, halogen, -C(=O)NH2 or cyano; R2 is absent or is halogen, lower alkoxy, hydroxy or lower alkyl; R3 is absent or is halogen, lower alkoxy, hydroxy or lower alkyl; R4 is absent or is morpholinyl-lower alkylenyl; X is CH or N; and Y is CH or N. Compounds of formula (I) inhibit Btk (Bruton's tyrosine kinase). Compounds of formula (I) are useful for modulating the activity of Btk and treating diseases associated with excessive Btk activity. Compounds are useful in the treatment of cancer, autoimmune and inflammatory diseases caused by aberrant B-cell activation. 
(I).
EFFECT: invention also relates to pharmaceutical compositions containing compounds of formula (I) and at least one carrier, diluent or excipient.
25 cl, 2 tbl, 20 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BRUTON'S TYROSINE KINASE INHIBITORS | 2014 |
|
RU2648236C2 |
| BRUTON'S TYROSINE KINASE INHIBITORS | 2014 |
|
RU2653504C2 |
| AMINOPYRAZOLE DERIVATIVE | 2010 |
|
RU2580543C9 |
| HETEROARYL PYRROLIDINYL AND PIPERIDINYL KETONE DERIVATIVES | 2007 |
|
RU2479575C2 |
| NOVEL COMPOUNDS AND FASN INHIBITION COMPOSITIONS | 2014 |
|
RU2737434C2 |
| PRIMARY CARBOXAMIDES AS BTK INHIBITORS | 2014 |
|
RU2708395C2 |
| INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | 2002 |
|
RU2337906C2 |
| MKK4 PROTEIN KINASE INHIBITORS FOR STIMULATION OF LIVER REGENERATION OR REDUCTION OR PREVENTION OF HEPATOCYTE DEATH | 2019 |
|
RU2788000C2 |
| PHENOXYMETHYL DERIVATIVES | 2016 |
|
RU2746481C1 |
| 2,6-SUBSTUTED-4-MONOSUBSTITUTED AMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | 2005 |
|
RU2417990C2 |
