AMINOPYRAZOLE DERIVATIVE Russian patent published in 2016 - IPC C07D401/14 C07D403/14 C07D405/14 C07D409/14 C07D413/14 C07D471/04 C07D491/56 A61K31/4184 A61K31/4439 A61K31/444 A61K31/4709 A61K31/496 A61K31/501 A61K31/5377 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound, which has formula

presented below, or a pharmaceutically acceptable salt thereof. This compound can inhibit fibroblast growth factor receptor (FGFR) kinases in tumour tissues. In formula (I) A means a heteroaryl specified in indole, azaindole, benzofuran, benzothiophene, benzorhiazole, quinoline and pyrrole, or a benzene ring; R₁ particularly means hydrogen, hydroxy, halogen, cyano, C_1-4 haloalkyl, C_1-6 alkyl, C_2-6 alkinyl; R₂ particularly means hydrogen, hydroxy, halogen, cyano, C_1-4 haloalkyl, C_1-6 alkyl, C_2-6 alkinyl, C_3-7 cycloalkyl, phenylC_1-4 alkyl, or R₁ and R₂ together with a nitrogen atom connected thereto form a 5-6-merous heterocyclyl group containing two oxygen atoms optionally substituted by a halogen; R₃ means H, C_1-5 alkyl group, phenylC_1-5 alkyl group or C_1-4 haloalkyl group; and R₄ means H or halogen.

EFFECT: invention refers to a pharmaceutical composition and an agent for FGFR inhibition, an agent for preventing or treating a malignant new growth, a method for preventing or treating malignant new growths, and the use of the compounds for producing a medicinal agent for preventing or treating malignant new growths.

10 cl, 35 tbl, 246 ex