FIELD: chemistry.
SUBSTANCE: invention relates to specific compounds which are (S)-4-(1-acryloylpiperidin-3-yl)-1H-indole-7-carboxamide, (R)-4-(1-acryloylpiperidin-3-yl)-1H-indole-7-carboxamide, 4-(1-acryloylpiperidin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide, 4-((1-acryloylazetidin-3-yl)(methyl)amino)-1H-indole-7-carboxamide, 4-(3-acrylamidophenyl)-2-(2-hydroxyethyl)-1H-indole-7-carboxamide, 4-(3-acrylamidophenyl)-2-ethyl-1H-indole-7-carboxamide, or a pharmaceutically acceptable salt thereof.
EFFECT: compounds of the present invention are useful as BTK inhibitors.
6 cl, 52 tbl, 30 ex
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Authors
Dates
2019-12-06—Published
2014-06-26—Filed