TREATMENT OF INFLAMMATION, AUTOIMMUNE, AND NEURODEGENERATIVE DISORDERS WITH IMMUNOSUPPRESSIVE TAT DERIVATIVE POLYPEPTIDES Russian patent published in 2018 - IPC C07K14/155 C07K19/00 A61K38/16 A61K39/21 A61P37/06 A61P25/28 A61P29/00 

FIELD: biotechnology.

SUBSTANCE: present invention relates to biotechnology, specifically to immunosuppressive polypeptides, which are trans-activator of transcription (Tat) derivatives, and can be used in medicine to treat an autoimmune disease, associated with an inflammation of a disease and/or a neurodegenerative disease. Immunosuppressive polypeptide comprises (i) a transcription factor (TF) domain, comprising a sequence of immunosuppressive human immunodeficiency virus (HIV), SIV Tat protein, hairless or artificial immunosuppressive sequence; (ii) a cysteine-rich domain from lentiviral Tat or a defensin molecule; and (iii) the C-terminal domain from the lentiviral protein Tat1.

EFFECT: invention enables to effectively inhibit an undesirable immune response in diseases characterised by aberrant immune responses.

14 cl, 17 dwg, 4 tbl, 8 ex