FIELD: biochemistry.
SUBSTANCE: invention relates to carbazole-containing sulfonamide derivatives of formula I and their pharmaceutically acceptable salts, as well as to pharmaceutical compositions comprising a compound of formula I for treatment of a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome and glaucoma. Also, methods for treating, alleviating and monitoring Cry-mediated diseases or disorders in a subject are provided.
EFFECT: for treatment of a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome and glaucoma.
39 cl, 8 ex, 4 tbl
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