VACCINE COMPOSITION Russian patent published in 2018 - IPC A61K39/12 A61K39/39 A61P31/12 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to immunology, and can be used to prepare a vaccine composition for administration to the oral cavity of a human or animal. Vaccine composition containing at least one antigen derived from an infectious disease, and at least one agent selected from the group consisting of a toll-like receptor 4 (TLR4) agonist. Where the toll-like receptor 4 (TLR4) agonist comprises at least one agent selected from the group consisting of a lipopolysaccharide or a salt thereof, where the lipopolysaccharide or its salt is derived from Escherichia coli, Salmonella, Pantoea, Acetobacterium, Zymomonas, Xanthomonas or Enterobacter.

EFFECT: use of TLR4 agonists is effective in inducing an immune response of the mucosa as an adjuvant in a vaccine for sublingual administration, causing increased production of IgG in combination with an infectious antigen.

5 cl, 13 dwg, 7 tbl, 18 ex