IMIDAZOPYRIDINE COMPOUNDS USEFUL IN TREATMENT OF CONDITION ASSOCIATED WITH P2X3 AND/OR P2X2/3 ACTIVITY Russian patent published in 2018 - IPC C07D471/04 A61K31/4025 A61K31/437 A61K31/4545 A61K31/5377 A61P13/00 

Abstract RU 2656593 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, specifically to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where R1 is selected from the group consisting of cyano, halogen and methyl; R2 is selected from the group consisting of hydrogen and halogen; R3 is selected from the group consisting of halogen and methyl; R4 is selected from the group consisting of hydrogen and halogen; R5 and R6 are independently selected from the group consisting of hydrogen and C1-C6-alkyl; R7 and R8 are independently selected from the group consisting of hydrogen and C1-C4-alkyl; R9 is selected from the group consisting of C1-C6-alkyl and C1-C6-alkoxy; and X is selected from CH2 and O. Invention also relates to a pharmaceutical composition based on a compound of formula (I) and use thereof. .

EFFECT: technical result: obtaining novel imidazopyridine derivatives, useful in the treatment of a condition associated with P2X2/3 activity.

24 cl, 2 dwg, 2 tbl, 49 ex

Similar patents RU2656593C2

Title Year Author Number
PROTEIN TYROSIN PHOSPHATASE INHIBITORS 2020
  • Blake, James F.
  • Boys, Mark Laurence
  • Chicarelli, Mark Joseph
  • Cook, Adam W.
  • Elsayed, Mohamed S. A.
  • Fell, Jay Bradford
  • Fischer, John P.
  • Hinklin, Ronald Jay
  • Jiang, Yutong
  • Mcnulty, Oren T.
  • Mejia, Macedonio J.
  • Rodriguez, Martha E.
  • Wong, Christina E.
RU2799449C2
COMPOUNDS, COMPOSITIONS AND METHODS FOR CFTR MODULATION 2016
  • Munoz, Benito
  • Bastos, Cecilia, M.
  • Parks, Daniel
  • Kombo, David
RU2752567C2
NOVEL BICYCLIC DERIVATIVES 2020
  • Dyukrej, Per
  • Potra, Fransua
  • Razho, Denis
  • Takhtavi, Shuajb
RU2830113C2
INFLUENZA VIRUS REPLICATION INHIBITORS, METHODS OF APPLICATION AND USING 2016
  • Zhang, Yingjun
  • Ren, Qingyun
  • Tang, Changhua
  • Lin, Xiaohong
  • Yin, Junjun
  • Yi, Kai
RU2737190C2
TRANSGLUTAMINASE 2 (TG2) INHIBITORS 2019
  • Campbell, David
  • Chapman, Justin
  • Cheung, Mui, H.
  • Diraimondo, Thomas, R.
  • Duron, Sergio, G.
RU2781370C2
BICYCLIC DERIVATIVES 2019
  • Dyukre, Per
  • Potra, Fransua
  • Razho, Deniz
  • Takhtaui, Shuaib
RU2794895C2
BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USING SAID COMPOUNDS FOR TREATING BACTERIAL INFECTIONS 2017
  • Liu, Weiguo
  • Ding, Fa-Xiang
  • Sun, Wanying
  • Dejesus, Reynalda, Keh
  • Tang, Haifeng
  • Huang, Xianhai
  • Jian, Jinlong
  • Guo, Yan
  • Wang, Hongwu
RU2733402C2
PRODRUGS OF CONJUGATED BICYCLIC C5aR ANTAGONISTS 2019
  • Fan, Pingchen
  • Lui, Rebecca M.
  • Singh, Rajinder
  • Mali, Venkat Reddy
  • Zeng, Yibin
  • Zhang, Penglie
RU2794327C2
MUSCARINIC RECEPTOR AGONISTS 2016
  • Brown Giles Albert
  • Congreve Miles Stuart
  • Pickworth Mark
  • Tehan Benjamin Gerald
RU2737158C2
BIARYL DERIVATIVES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTION YAP/TAZ-TEAD 2021
  • Bordas, Vincent
  • Brocklehurst, Cara
  • Chene, Patrick
  • Fei, Zhongbo
  • Furet, Pascal
  • Guagnano, Vito
  • Imbach-Weese, Patricia
  • Kallen, Joerg
  • Le Douget, Mickael
  • Li, Jialiang
  • Li, Wei
  • Lorthiois, Edwige Liliane Jeanne
  • Mckenna, Joseph
  • Salem, Bahaa
  • Schmelzle, Tobias
  • Sellner, Holger
  • Soldermann, Nicolas
  • Voegtle, Markus
  • Wartmann, Markus
RU2830596C1

RU 2 656 593 C2

Authors

Buon Christophe

Cantin Louis-David

Hu Yun-Jin

Luo Xuehong

Tomaszewski Miroslaw Jerzy

Dates

2018-06-06Published

2014-01-31Filed