IMIDAZOPYRIDINE COMPOUNDS USEFUL IN TREATMENT OF CONDITION ASSOCIATED WITH P2X3 AND/OR P2X2/3 ACTIVITY Russian patent published in 2018 - IPC C07D471/04 A61K31/4025 A61K31/437 A61K31/4545 A61K31/5377 A61P13/00 

Abstract RU 2656593 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, specifically to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where R1 is selected from the group consisting of cyano, halogen and methyl; R2 is selected from the group consisting of hydrogen and halogen; R3 is selected from the group consisting of halogen and methyl; R4 is selected from the group consisting of hydrogen and halogen; R5 and R6 are independently selected from the group consisting of hydrogen and C1-C6-alkyl; R7 and R8 are independently selected from the group consisting of hydrogen and C1-C4-alkyl; R9 is selected from the group consisting of C1-C6-alkyl and C1-C6-alkoxy; and X is selected from CH2 and O. Invention also relates to a pharmaceutical composition based on a compound of formula (I) and use thereof. .

EFFECT: technical result: obtaining novel imidazopyridine derivatives, useful in the treatment of a condition associated with P2X2/3 activity.

24 cl, 2 dwg, 2 tbl, 49 ex

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RU 2 656 593 C2

Authors

Buon Christophe

Cantin Louis-David

Hu Yun-Jin

Luo Xuehong

Tomaszewski Miroslaw Jerzy

Dates

2018-06-06Published

2014-01-31Filed