METHOD OF MANUFACTURE OF TABLETS Russian patent published in 2018 - IPC A61J3/10 A61K9/20 A61K31/00 A61K47/00 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to the pharmaceutical industry and can be used in the production technology of tablets. Process for the production of tablets includes mixing powders with different granulometric compositions, namely, an active pharmaceutical substance and ancillary substances, such as binders, fillers, disintegrating agents. Mixing is carried out in a high-speed centrifugal bladed mixer at a frequency of 70–750 rpm for 20–300 s. Granulation in a fluidized bed is then carried out at a temperature of 40–80 °C, feed rate of the granulating solution of the binder is 60–300 g/min and the concentration of the binder solution is 0.5–30.0 %. Then, the granulate is calibrated on a vertical cone calibrator with a rotor frequency of 80–600 rpm and a mesh diameter of 0.45–2 mm and subsequent tableting is carried out on a rotary press.

EFFECT: invention provides narrowing of the particle size distribution and displacement of the distribution towards smaller particles, as well as expansion of the list of manufactured products.

4 cl, 1 dwg, 1 ex, 1 tbl