FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to chemical-pharmaceutical industry, and can be applied in technology of pill production. After granulation in pseudoliquefied layer in dispersion carried out is calibration of granulated material on vertical conical calibrator with following process parametres: rotor speed - 2-5 rot/sec; gap between grid and rotor - 1-3 mm; diametre of grid cell - 1-2 mm. Active pharmaceutical substance is selected from group, which includes enalapril, captopril, methionine. Binding agent is selected from group, which includes polyvinylpyrrolydone, methylcellulose, gelatin, starch, copolymer of vinylpyrrolydone with vinylacetate, sucrose, vegetable extracts.
EFFECT: method of obtaining pills makes it possible to increase dosing accuracy by prevention of stratification of multi-component pilled masses, due to improvement of components and their mixtures friability and ensuring evenness of their supply to matrix of pill machine.
7 cl, 3 ex, 12 tbl
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