AMIDES AS MODULATORS OF SODIUM CHANNELS Russian patent published in 2018 - IPC C07D213/79 C07C235/64 A61K31/44 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to amide compounds of formula I and I′:

where: Y is CH or N; R¹ is H or C₁-C₆ alkyl, where said C₁-C₆ alkyl is substituted with 0-6 halogens; R² is H, halogen or C₁-C₆ alkyl, wherein said C₁-C₆ alkyl is substituted with 0-6 halogens; R³ is H, halogen or C₁-C₆ alkyl, wherein said C₁-C₆ alkyl is substituted with 0-6 halogens; R⁴ is H; R⁵ is H, halogen, or -X-R^X; R^5' is H; R⁶ is H or halogen; R^6' is H or halogen; R⁷ is H, halogen or -X-R^X; X is a bond or C₁-C₆ alkyl, where said C₁-C₆ alkyl is substituted with 0-6 halogens, where up to two non-adjacent CH₂ links of the C₁-C₆ alkyl may be replaced by -O-; R^X is absent or is H; p is 0; or to pharmaceutically acceptable salts thereof.

EFFECT: invention is used as inhibitors of sodium channels for the treatment of various disorders, including pain.

45 cl, 3 tbl, 13 ex