PRODRUGS OF PYRIDONAMIDES USED AS MODULATORS OF SODIUM CHANNELS Russian patent published in 2019 - IPC C07D213/18 A61K31/675 A61P19/02 C07F9/576 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention refers to prodrug compounds of formula I:

I, wherein: R² and R³ independently represent hydrogen, halogen or C₁-C₆-alkyl, where said C₁-C₆-alkyl is substituted with 0–6 halogen atoms; R⁵ is hydrogen, halogen, OH or C₁-C₆-alkyl, where said C₁-C₆-alkyl is substituted with 0–6 halogen atoms and where up to two non-adjacent links of CH₂ said C₁-C₆-alkyl can be replaced with -O-; R⁷ is hydrogen, halogen or C₁-C₆-alkyl, where said C₁-C₆-alkyl is substituted with 0–6 halogen atoms and where up to two non-adjacent links of CH₂ said C₁-C₆-alkyl can be replaced with -O-; and X is -PO(OH)₂, -PO(OH)O^-M⁺, -PO(O^-)₂⋅2M⁺ or -PO(O^-)₂D²⁺; M⁺ is a pharmaceutically acceptable monovalent cation; and D²⁺ is a pharmaceutically acceptable bivalent cation; which are used for treating various disorders, including pain.

EFFECT: prodrugs of pyridonamides used as modulators of sodium channels are proposed.

74 cl, 6 dwg, 9 tbl, 15 ex