PRODRUGS OF PYRIDONAMIDES USED AS MODULATORS OF SODIUM CHANNELS Russian patent published in 2019 - IPC C07D213/18 A61K31/675 A61P19/02 C07F9/576 

Abstract RU 2692766 C1

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention refers to prodrug compounds of formula I:

I, wherein: R2 and R3 independently represent hydrogen, halogen or C1-C6-alkyl, where said C1-C6-alkyl is substituted with 0–6 halogen atoms; R5 is hydrogen, halogen, OH or C1-C6-alkyl, where said C1-C6-alkyl is substituted with 0–6 halogen atoms and where up to two non-adjacent links of CH2 said C1-C6-alkyl can be replaced with -O-; R7 is hydrogen, halogen or C1-C6-alkyl, where said C1-C6-alkyl is substituted with 0–6 halogen atoms and where up to two non-adjacent links of CH2 said C1-C6-alkyl can be replaced with -O-; and X is -PO(OH)2, -PO(OH)O-M+, -PO(O-)2⋅2M+ or -PO(O-)2D2+; M+ is a pharmaceutically acceptable monovalent cation; and D2+ is a pharmaceutically acceptable bivalent cation; which are used for treating various disorders, including pain.

EFFECT: prodrugs of pyridonamides used as modulators of sodium channels are proposed.

74 cl, 6 dwg, 9 tbl, 15 ex

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RU 2 692 766 C1

Authors

Anderson Kori

Adida-Rua Sara Sabina

Golek Dzhulian Merian Charlz

Chzhan Bejli

Littler Bendzhamin Dzhozef

Keskhavarz-Skhokri Ali

Alkasio Tim Edvard

Belmont Deniel T.

Dates

2019-06-27Published

2014-12-12Filed