α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE INHIBITORS Russian patent published in 2025 - IPC C07D409/14 C07D409/04 C07D401/12 C07D213/85 A61K31/4412 A61P3/00 A61P13/12 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (II):

or a pharmaceutically acceptable salt or tautomer thereof, where: X is O or OH; W is N; L is -(C(R⁵)₂)_mY¹(C(R⁵)₂)_p-; Y¹ is S; R¹ is absent or represents C₆-C₁₀ arylene; each R⁵ in each occurrence is independently H; each R⁶ in each occurrence is independently H; R⁷ is A or C; A is -(C(R⁶)₂) r tetrazole, C is -(C(R⁶)₂)_rC₆-C₁₀ aryl, wherein said aryl is substituted with one to three substitutes, each independently selected from halogen and OH; R^c is H or -CN; R^d is CF₃, -(C(R⁶)₂)_tC₆-C₁₀ aryl; R^f is H; R^j is absent; each m, p, q and r is independently 0, 1 or 2; each t is 1 or 2; and is a single bond or a double bond, which are capable of inhibiting decarboxylase activity of semialdehyde α-amino-β-carboxymuconic acid (ACMSD). Present application also describes pharmaceutical compositions, use of said compounds as a medicinal agent.

EFFECT: compounds are suitable for preventing and/or treating diseases and disorders associated with disorders of NAD⁺ biosynthesis, for example, metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, renal diseases and diseases associated with aging.

54 cl, 1 tbl, 98 ex