FIELD: chemistry.
SUBSTANCE: invention relates to process for production of 7-alkyl-2,3-dihydro-1H-pyrrolo[1,2-d][1,4]diazepine-4(5H)-one derivatives of formula 1, which can find application as substances possessing potential biological activity of a wide spectrum of action. Method for preparation of the 7-alkyl-2,3-dihydro-1H-pyrrolo[1,2-d][1,4]diazepin-4(5H)-one derivatives 1 is based on the simultaneous formation of two cycles of the pyrrolodiazepine framework as a result of the successive treatment of a mixture of alpha-amino acids and 2-(furan-2-yl)ethylamines with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-methylmorpholine in 1,2-dichloroethane, then a mixture of hydrochloric and acetic acids at room temperature and further cyclization by the method of Paal-Knorr by boiling in acetic acid for 30 minutes. Method allows the synthesis of 7-alkyl-2,3-dihydro-1H-pyrrolo[1,2-d][1,4]diazepin-4(5H)-one 1 derivatives with high yields.
EFFECT: new method for preparation of 7-alkyl-2,3-dihydro-1H-pyrrolo[1,2-d][1,4]diazepin-4(5H)-one 1 derivatives has been developed.
1 cl, 2 tbl, 5 ex
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