FIELD: organic chemistry.
SUBSTANCE: new biologically active compounds - substituted pyrrolo[1,2-d][1,4]diazepinones, namely 5-[(1 H-indol-3-yl)methyl]-7-methyl -2,3-dihydro-1 H-pyrrolo[1,2-d][1,4]diazepin-4(5 H )-one of Formula 1, which has antimycotic activity, which suggests its use in medicine as a potential drug with antimycotic properties. The use of 5-[(1H-indol-3-yl)methyl]-7-methyl-2,3-dihydro-1H-pyrrolo[1,2-d][1,4]diazepin-4(5H)-one as an antifungal agent against yeast fungi.
EFFECT: invention provides 5-[(1H-indol-3-yl)methyl]-7-methyl-2,3-dihydro-1H-pyrrolo[1,2-d][1,4]diazepin-4(5H)-one with a pronounced antimycotic effect and low toxicity.
1 cl, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| APPLICATION OF 10-METHYL-6,7-DIHYDRO-5H-PYRIDO[2,3-b]-PYRROLO[1,2-d][1,4]DIAZEPINE AS AN ANTIFUNGAL AGENT AGAINST YEASTS | 2023 |
|
RU2803600C1 |
| USE OF 5-(4-METOXYPHENYL)-7-METHYL-1,2,4,5-TETRAHYDRO-3H-PYRROLO[1,2-a][1,4]DIAZEPIN-3-ONE AS AN ANTIFUNGAL AGENT AGAINST YEAST FUNGI | 2023 |
|
RU2810715C1 |
| USE OF 7-METHYL-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4,5-TETRAHYDRO-3H-PYRROLO[1,2-a][1,4]DIAZEPIN-3-ONE AS AN ANTIFUNGAL AGENT AGAINST YEAST FUNGI | 2023 |
|
RU2808981C1 |
| USE OF 7-METHYL-2-(4-METHYLPHENYL)-1,2,4,5-TETRAHYDRO-3H-PYRROLO[1,2-a][1,4]DIAZEPIN-3-ONE AS AN ANTIFUNGAL AGENT AGAINST YEAST FUNGI | 2023 |
|
RU2809053C1 |
| USE OF 2-METHYL-4-[7-(TRIFLUOROMETHYL)PHENYL]-1,2,4,5-TETRAHYDRO-3H-PYRROLO[1,2-a][1,4]DIAZEPIN-3-ONE AS ANTIFUNGAL AGENT AGAINST YEAST FUNGI | 2023 |
|
RU2809051C1 |
| USE OF 1-METHYL-5-(4-CHLOROPHENYL)-4,5-DIHYDRO-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPIN-6-ONE AS AN ANTIFUNGAL AGENT AGAINST YEAST FUNGI | 2023 |
|
RU2809148C1 |
| USE OF 1-METHYL-8,9-DIMETHOXY-4,5-DIHYDRO-6H-PYRROLO[1,2-A][1,4]BENZODIAZEPIN-6-ONE AS AN ANTIFUNGAL AGENT AGAINST YEAST FUNGI | 2023 |
|
RU2808993C1 |
| APPLICATION OF 5-ISOPROPYL-7-METHYL-2,3-DIHYDRO-1H-PYRROLO[1,2-d][1,4]DIAZEPIN-4(5H)-ONE AS ANTIBACTERIAL AGENT AGAINST GRAM-POSITIVE MICROORGANISMS | 2022 |
|
RU2784439C1 |
| USE OF 1-METHYL-4,5-DIHYDRO-6H-PYRIDO[1,2-a][1,4]BENZODIAZEPINE-6-ONE AS ANTIFUNGAL AGENT AGAINST YEASTS | 2023 |
|
RU2809026C1 |
| USE OF 4,6-DIMETHYL-1,2-DIHYDROPYRROLO[1,2-a]PYRAZIN-3(4H)-ONE AS AN ANTIFUNGAL AGAINST YEASTS | 2023 |
|
RU2806191C1 |
