FIELD: medicine.
SUBSTANCE: invention relates to pharmaceutics and medicine and is a prolonged-action therapeutic agent based on anastrozole in the form of lyophilizate for the preparation of a suspension for intramuscular administration, containing anastrozole (10.0÷15.0 mass%), lactic and glycolic acid copolymer (70.0÷76.0 mass%), D-mannitol (12.0÷14.0 mass%), polyvinyl alcohol (0.01÷0.5 mass%), methylcellulose (0.01÷0.5 mass%).
EFFECT: invention has a convenient method and mode of administration, an optimal composition and characteristics providing increased duration and effectiveness of the action, which will allow using the therapeutic agent in the treatment of patients with estrogen-dependent breast cancer.
1 cl, 2 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROLONGED-RELEASE ANTITUMOUR THERAPEUTIC AGENT BASED ON ANASTROZOLE, ANTITUMOUR PREPARATION, OESTROGEN SYNTHESIS INHIBITOR | 2013 |
|
RU2548722C1 |
| COMPOSITION CONTAINING COMBINATION OF AROMATASE INHIBITOR, PROGESTIN AND ESTROGEN, AND ITS APPLICATION FOR ENDOMETRIOSIS TREATMENT | 2004 |
|
RU2360681C2 |
| DRUG OF ANTI-TUBERCULOSIS ACTION ON THE BASIS OF D-CYCLOSERINE IN THE FORM OF A LYOPHILISATE AND METHOD OF PRODUCING A MEDICINAL PREPARATION | 2015 |
|
RU2606839C1 |
| ANTI-INFLAMMATORY PREPARATION BASED ON KETOPROFEN AND A METHOD FOR PRODUCTION THEREOF | 2018 |
|
RU2694221C1 |
| FULVESTRANT COMPOSITIONS | 2001 |
|
RU2263507C2 |
| INTERPOLYMER MATERIAL FOR MEDICAL AND VETERINARY USE AND PROLONGED MEDICINAL AND VETERINARY AGENTS ON ITS BASIS | 2017 |
|
RU2684608C1 |
| APPLICATION OF FULVESTRANT AT TREATING RESISTANT CANCER OF MAMMARY GLAND | 2001 |
|
RU2265438C2 |
| PHARMACEUTICAL COMPOSITION FOR PARENTERAL DELIVERY IN FORM OF LYOPHILIZATE AND METHOD OF ITS OBTAINING | 2007 |
|
RU2370258C2 |
| POLYMER CONTAINING MEDICINAL AGENT BASED ON ANTITUMOR AGENT ETOPOSIDE | 2015 |
|
RU2595859C1 |
| SUSTAINED RELEASE SYSTEMS AND LOW DOSES OF ANDROGENS, METHODS OF THEIR PREPARING AND METHOD OF TREATMENT USING THESE SYSTEMS | 1992 |
|
RU2142276C1 |
