COMBINED PRODUCTS CONTAINING TYROSINE KINASE INHIBITORS AND THEIR USE Russian patent published in 2018 - IPC A61K31/5377 A61K31/4985 A61P35/00 

Abstract RU 2660354 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to the treatment of proliferative diseases. Pharmaceutical combination for the treatment of a malignant lung tumour, comprising (i) a MET tyrosine kinase inhibitor 2-fluoro-N-methyl-4-[(7-quinolin-6-ylmethyl)imidazo[1,2-b]triazin-2-yl]benzamide or a pharmaceutically acceptable salt thereof and (ii) an EGFR tyrosine kinase inhibitor gefitinib, and at least one pharmaceutically acceptable carrier; its use for the treatment of a malignant lung tumour, a method for treating a malignant lung tumour using this pharmaceutical combination (versions) and use of an inhibitor of EGFR gefitinib and a MET inhibitor 2-fluoro-N-methyl-4-[(7-quinolin-6-ylmethyl)-imidazo[1,2-b]triazin-2-yl]-benzamide or a pharmaceutically acceptable salt thereof, for the preparation of a pharmaceutical combination for the treatment of a malignant lung tumour.

EFFECT: technical result consists in the synergism of the action of the disclosed combination against a malignant lung tumour.

6 cl, 5 dwg, 3 tbl, 5 ex

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RU 2 660 354 C2

Authors

Tidt Ralf

Shatene-Rivode Kristian

Ito Moriko

Pen Bin

Gun In

Akimov Mikhail

Dates

2018-07-05Published

2013-04-03Filed