PYRIDINE DERIVATIVES AS INHIBITORS OF VASCULAR ENDOTHELIUM GROWTH FACTOR RECEPTORS 2 (VEGFR-2) AND PROTEIN TYROSINE KINASE Russian patent published in 2014 - IPC C07D213/75 C07D405/12 C07D413/12 A61K31/443 A61K31/444 A61P17/00 A61P27/00 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of organic chemistry, namely to compounds of the general formula I , and its pharmaceutically acceptable salts, where R₁, R₂ and R₃ represent hydrogen, D, E, G, J and L represent CH; n equals to an integer number 1 or 2; W represents oxygen; R₄ represents C_1-6alkyl, C_3-6cycloalkyl, C_3-6cycloalkenyl, where the said C_1-6alkyl is possibly substituted with one substituent, independently selected from a group, consisting of hydrogen, C_1-4alkyl, C_3-6cycloalkyl and C_3-6cycloalkenyl; Y represents carbonyl; R₅ represents C_1-6alkyl, C_1-6alkoxy or C_3-4heteroaryl, which represents a heterocyclic aromatic ring, containing 1-2 heteroatoms, selected from nitrogen and oxygen. The invention also relates to a pharmaceutical composition based on a formula I compound, application of the formula I compound and a method of prevention, treatment of alleviation of a disease, associated with abnormal angiogenesis.

EFFECT: obtained are novel compounds useful in treatment of diseases associated with unregulated angiogenesis, such as cancer, as well as skin and eye diseases.

13 cl, 3 tbl, 11 ex