IMMUNE MODULATION Russian patent published in 2018 - IPC C12N15/86 A61K39/35 A61K39/275 A61K39/285 C12N7/01 C12N15/62 

FIELD: biotechnology.

SUBSTANCE: inventions relate to the field of biotechnology and relate to a poxviral vector, a composition comprising such a vector, a method for desensitization, induction of tolerability or suppression of an allergic reaction, a method for vaccinating a subject and a kit. Represented vector includes a nucleotide sequence encoding a fusion protein comprising (i) at least two peanut allergens selected from the group consisting of ara h 1, ara h 2, ara h 3, ara h 4, ara h 5, ara h 6, ara h 7, ara h 8, ara h 9, ara h 10 and ara h 11, and (ii) a mark of proteasome degradation to enhance intracellular degradation of the fusion protein, wherein the vector comprises a transcription control sequence and a start codon for encoding the expression of the fusion protein and where the tag of proteasome degradation includes the ubiquitin monomer.

EFFECT: inventions can be used to prevent allergy to peanut and to facilitate its tolerability.

25 cl, 11 dwg, 2 tbl, 2 ex