FIELD: biotechnology.
SUBSTANCE: method for obtaining molecular structures with immunoregulatory properties containing antigenic epitopes of topical allergens and an ornithine decarboxylase signal peptide (ODCsig) is proposed. The gene encoding the protein-allergen by cloning is obtained, the ODCsig sequences are selected, the DNA sequences encoding the ODCsig signal peptides are cloned, the chimeric gene and the DNA constructs are developed to express the chimeric protein-allergens in bacterial cells.
EFFECT: invention provides specific immunotherapy for patients with allergies.
10 dwg, 2 tbl, 15 ex
