ALTERNATIVE COMPOSITIONS FOR TNFR:FC CHIMERICAL POLYPEPTIDES Russian patent published in 2018 - IPC A61K38/17 A61K47/02 A61K47/12 A61K47/26 C07K16/24 

FIELD: biochemistry.

SUBSTANCE: group of inventions relates to biochemistry. Aqueous composition having an inhibitory effect on TNF (variants) is proposed. In a first embodiment, the aqueous composition comprises an isolated polypeptide, a salt in a concentration of 80 to 130 mM, an aqueous buffer at a concentration of 20–30 mM, and sucrose at a concentration of 34–80 mg/ml. In this composition, arginine and cysteine are not presented. In a second embodiment, the aqueous composition comprises an isolated polypeptide, a salt in a concentration of 80 to 130 mM, wherein the salt is not present at a concentration of 100 mM, a succinate buffer selected from trehalose and sucrose, or a combination thereof. No free amino acids are present in said composition. Isolated polypeptide in each composition is an extracellular ligand-binding part of the human p75 tumor necrosis factor receptor fused to the human IgG1 Fc domain.

EFFECT: invention provides an aqueous composition having high stability at high temperatures without arginine and cysteine.

41 cl, 15 dwg