LIQUID COMPOSITION OF POLYPEPTIDES CONTAINING FC DOMAIN OF IMMUNOGLOBULIN Russian patent published in 2016 - IPC A61K38/17 A61K31/198 A61K47/02 A61K47/26 A61P29/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and is aimed at treating inflammatory diseases associated with TNF-α. Proposed is a water composition containing 50 mg/ml of etanercept, 1.3mg/ml of aspartic acid as the aggregation inhibitor, 1.5 mg/ml of lysine as the aggregation inhibitor and the stabilizer, 1.5 mg/ml of single-substituted sodium phosphate, 3.3 mg/ml of secondary acidic potassium phosphate, 20 mg/ml of sucrose, 5.8 mg/ml of sodium chloride, 0.37 mg/ml of a disodium salt of EDTA (ethylene diamine tetraacetic acid), 0.1 mg/ml of polysorbate 20 at the pH of 6.3.

EFFECT: invention provides improved stability for a long period of time.

1 cl, 15 dwg, 12 tbl, 7 ex