METHOD FOR CLEANING FIBRINOGEN, FIBRINOGEN PRODUCT AND MEANS FOR CLEANING OR PRODUCING FIBRINOGEN PRODUCT Russian patent published in 2018 - IPC C07K14/75 C07K1/36 

FIELD: biochemistry.

SUBSTANCE: method for purifying fibrinogen from a fibrinogen-containing source, a fibrinogen product for pharmaceutical use obtained by the above method (variants), and a means for purifying or producing the fibrinogen product. Method comprises pretreating a fibrinogen-containing source to form a fibrinogen-containing solution, precipitation of fibrinogen from the solution in the presence of one or more Ca²⁺chelating agents and removing the supernatant from the fibrinogen paste. Moreover, fibrinogen is extracted from the forming fibrinogen-containing liquid fraction and undissolved paste residue, where the insoluble residue separates from the liquid in the absence of a protease inhibitor. Means for purifying or producing a fibrinogen product is an anion exchange resin.

EFFECT: invention provides a concentrate of fibrinogen produced with the intended elimination of pathogens and/or inactivation steps in the preparation process.

30 cl, 2 dwg, 1 tbl, 1 ex