TETRAHYDROPYRIDO[3,4-B]INDOLE DERIVATIVES USEFUL IN TREATMENT OF CANCER Russian patent published in 2018 - IPC C07D471/04 A61K31/437 A61P35/00 

Abstract RU 2664109 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, particularly to a compound of formula (I) or an isomer thereof or a pharmaceutically acceptable salt thereof, where R1 and R2 each independently represents H or F; R3 is H or methyl; and either a) R4 is H, and R5 is F; or b) R4 is F, and R5 is H. Invention also relates to a method for preventing or treating cancer, a pharmaceutical composition and a combination based on a compound of formula (I).

.

EFFECT: novel heterocyclic compound useful in the treatment of cancer is obtained.

14 cl, 12 dwg, 2 tbl, 15 ex

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RU 2 664 109 C2

Authors

Akhtar Nadim

Bradbury Robert Hugh

Buttar David

Currie Gordon Stuart

De Savi Christopher

Donald Craig Samuel

Norman Richard Albert

Osborne Matthew

Rabow Alfred Arthur

Redfearn Heather Marie

Williams Helen Elizabeth

Yavari Neda

Dates

2018-08-15Published

2014-05-27Filed