FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, in particular to a heterocyclic compound of formula I or to a pharmaceutically acceptable salt thereof where X is -O-; Y is or ; each R1 and R2 is hydrogen; each R3 and R4 is independently selected from hydrogen and halogen, and when one of R3 or R4 is a halogen, the other of R3 or R4 is hydrogen; R5 is a C1-C6alkyl or C1-C6haloalkyl; R6 is a C1-C6haloalkyl; and each R7 and R8 is independently selected from hydrogen and C1-C66alkyl. The invention also relates to a pharmaceutical composition based on a formula I compound and to a method for treating an estrogen-mediated disruption, which involves introducing a formula I compound.
EFFECT: technical result is that new heterocyclic compounds have been produced, useful for the treatment of certain cancers, such as breast cancer, ovarian cancer, etc.
47 cl, 11 dwg, 4 tbl, 21 ex
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Authors
Dates
2021-03-31—Published
2016-09-29—Filed