TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE ANTI-ESTROGENIC DRUGS Russian patent published in 2021 - IPC C07D471/04 A61K31/437 A61P5/32 A61P35/00 

Abstract RU 2745742 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, in particular to a heterocyclic compound of formula I or to a pharmaceutically acceptable salt thereof where X is -O-; Y is or ; each R1 and R2 is hydrogen; each R3 and R4 is independently selected from hydrogen and halogen, and when one of R3 or R4 is a halogen, the other of R3 or R4 is hydrogen; R5 is a C1-C6alkyl or C1-C6haloalkyl; R6 is a C1-C6haloalkyl; and each R7 and R8 is independently selected from hydrogen and C1-C66alkyl. The invention also relates to a pharmaceutical composition based on a formula I compound and to a method for treating an estrogen-mediated disruption, which involves introducing a formula I compound.

EFFECT: technical result is that new heterocyclic compounds have been produced, useful for the treatment of certain cancers, such as breast cancer, ovarian cancer, etc.

47 cl, 11 dwg, 4 tbl, 21 ex

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RU 2 745 742 C1

Authors

Myles, David, C.

Kushner, Peter, J.

Harmon, Cyrus, L.

Dates

2021-03-31Published

2016-09-29Filed