TARTARE SALT [(S)-2-[METHYL-3-(2-OXO-PYRROLIDIN-1-YL)- BENZENESULFONYLAMINO]-3-(4-METHYL-PIPERAZINE-1-YL)-3-OXO-PROPYL]AMIDE 5-CHLORINE-THIOPHENE-2- CARBOXYLIC ACID Russian patent published in 2018 - IPC C07D409/14 A61K31/381 A61P9/10 

Abstract RU 2664538 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a tartrate salt of [(S)-2-[methyl-3-(2-oxo-pyrrolidine-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazine-1-yl)-3-oxo-propyl]amide 5-chlorine-thiophene-2-carboxylic acid.

EFFECT: invention relates to the therapeutic use of a tartrate salt as an inhibitor of the coagulation factor Xa and thrombin.

8 cl, 1 dwg, 7 tbl

Similar patents RU2664538C2

Title Year Author Number
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR TREATING OSTEOARTHRITIS 2015
  • Brebion Franck Laurent
  • Alvey Luke Jonathan
  • Amantini David
  • Deprez Pierre Marc Marie Joseph
  • Gosmini Romain Luc Marie
  • Jary Helene Marie
  • Peixoto Christophe
  • Varin Marie Laurence Claire
  • De Ceuninck Frederic Andre
  • Pop-Botez Iuliana Ecaterina
RU2693459C2
SUBSTITUTED DERIVATIVES OF 1-OXA-2,8-DIAZASPIRO[4,5]DEC-2-ENE, METHOD FOR PRODUCTION THEREOF AND DRUG HAVING ANALGESIC ACTION 2002
  • Bushmann Khel'Mut Genrikh
  • Ehngl'Berger Verner Gjunter
  • Germann Tino
  • Khennis Khagen-Genrikh
  • Maul' Korinna
  • Zundermann Bernd
  • Kholents Jerg
RU2296128C2
METHOD OF PRODUCING 7-/2-(2-AMINOTHIAZOLE-4-YL)-/Z/-2-(2-CARBOXY-PROP-2-OXYIMINO)ACETAMIDO/-3-/(1-METHYL-1-PYRROLIDINIUM)METHYL/-3-CEPHEM-4-CARBOXYLATE 0
  • Simpei Aburaki
  • Khadzime Kamati
  • Yukio Narita
  • Yun Okumura
  • Takayuki Naito
SU1326195A3
METHOD FOR SYNTHESIS OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)-PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2-THIOPHENECARBOXAMIDE 2004
  • Berve Matias
  • Tomas Kristian
  • Reze Joakhim
  • Grotjokhann Dirk
RU2383540C2
1-[M-CARBOXAMIDO(HETERO)ARYL-METHYL]-HETEROCYCLYL-CARBOXAMIDE DERIVATIVES 2013
  • Fretts Khajnts
  • Gude Markus
  • Gerri Filipp
  • Kimmerlen Terri
  • Leembre Fransua
  • Pfajfer Tomas
  • Valdener Anya
RU2644761C2
SUBSTITUTED 3-OXO-1,2,3,4-TETRAHYDROXINOXALINES, PHARMACEUTICAL COMPOSITIONS (VARIANTS), METHODS FOR PRODUCTION AND USES THEREOF 2003
  • Ivashchenko A.V.
  • Kobak V.V.
  • Il'In A.P.
  • Kravchenko D.V.
  • Tkachenko S.E.
  • Okun' Il'Ja Matusovich
RU2251546C1
DERIVATIVES OF 2- PYRROLIDINE-2-YL-[1, 3, 4]OXADIAZOLE AND THEIR USE AS ANTIDEPRESSANT AGENTS 2003
  • Khagen-Genrikh Khenniz
  • Korinna Zundermann
  • Khel'Mut Bushmann
  • Bernd Zundermann
RU2324694C2
DERIVATIVES OF 2-OXO-1-PYRROLIDINE, METHOD FOR THEIR PREPARING AND USING 2001
  • Differdehn Ehdmon
  • Kenda Benua
  • Ljallemehn Benedikt
  • Matan' Alen
  • Mishel' Filipp
  • Pazo Patrik
  • Talaga Patris
RU2291860C2
ANTIBIOTIC DERIVATIVES OF 2-OXO-OXAZOLIDINE-3, 5-DIYL 2012
  • Khubshverlen Kristian
  • Ryuedi Georg
  • Syurive Zhan-Filipp
  • Tsumbrunn-Aklen Korneliya
RU2616609C2
DERIVATIVES OF 2-OXO-1-PYRROLIDINE, METHODS FOR THEIR PREPARING AND USING 2001
  • Sartis Dzhon
  • Marmon Violeta
  • Differdehn Ehdmon
  • Zimmermann Vinsent
RU2292336C2

RU 2 664 538 C2

Authors

Lyafferrer Loran

Vijon Sebasten

Gote Sandrin

Burbon Andre

Dates

2018-08-20Published

2014-04-25Filed