FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to novel derivatives of 2-oxo-1-pyrrolidine of the general formula: (A) 
and their pharmaceutically acceptable salts wherein X means -CONR5R6, -COOR7 or -COR8; R1 represents hydrogen (H), halogen atom, (C1-C6)-alkyl; R2 and R4 are similar or different and each means independently H, halogen atom, (C1-C6)-alkyl; R3 means H, halogen atom, (C1-C6)-alkyl substituted with one or more halogen atoms, (C2-C5)-alkenyl; R, R6 and R7 are similar or different and each means independently H, (C1-C6)-alkyl; R8 means -OH, (C1-C6)-alkyl. Compounds of the formula (A) can be used for synthesis of (S)-(-)-α-ethyl-2-oxo-1-pyrrolidine acetamide. Also, invention describes methods for synthesis of compound of the formula (A).
EFFECT: improved methods of synthesis.
11 cl, 3 tbl, 13 sch, 6 ex
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