FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide by reacting 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]-phenyl}-morpholin-3-one-hydrochloride with 5-chlorothiophene-2-carbonyl chloride, distinguished by that the reaction is carried out in a solvent selected from ether, alcohol, ketone and water or a mixture thereof using an inorganic base.
EFFECT: design of a simple method for synthesis of said thiophenecarboxamide without use of toxic solvents.
13 cl, 1 ex
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|---|---|---|---|
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|
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RU2551852C2 |
