FIELD: medicine.
SUBSTANCE: invention relates to the treatment of congenital adrenal hyperplasia. The use of a CRF1 receptor antagonist, which is 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine (SSR-125543), or a pharmaceutically acceptable salt thereof, for the treatment of congenital adrenal hyperplasia.
EFFECT: invention provides inhibition of ACTH (adrenocorticotropic hormone) release in patients with CAH (congenital adrenal hyperplasia), thus ensuring normalization of androgen formation with a lower, more physiological dose of hydrocortisone and reduced treatment-related side effects.
3 cl, 6 dwg, 2 tbl, 6 ex
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