BACTERIALLY DERIVED, INTACT MINICELLS FOR DELIVERY OF THERAPEUTIC AGENTS TO BRAIN TUMOURS Russian patent published in 2018 - IPC A61K35/66 A61K47/46 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, specifically to oncology, and can be used in a subject to treat a brain tumour that has blood vessels with holes in its walls. To this end, a therapeutically effective amount of a composition consisting of intact bacterially derived minicells having a diameter of 400 nm ± 50 nm is systemically administered to a subject with a tumour. Each minicell contains an antibody that specifically recognises the antigen of tumour cells. Each minicell contains an antineoplastic agent. Minicells passively pass through openings in the walls of blood vessels. Also disclosed is use a composition containing said minicells to prepare a medicament for treating a brain tumour.

EFFECT: group of inventions provides treatment of brain tumours by accumulation of minicells containing an antineoplastic agent, in the microenvironment of the brain tumour and the delivery of the antineoplastic agent directly to the tumour cells, without endothelial endocytosis/transcytosis through the blood-brain barrier.

44 cl, 2 tbl, 13 dwg, 10 ex