FIELD: chemistry.
SUBSTANCE: invention describes substituted derivatives of steroids which are selective inhibitors of type I 17β-hydroxysteroid dehydrogenase 17β-HSD1 and which can also be steroid sulphatase inhibitors, as well as salts thereof, pharmaceutical agents containing said compounds. The invention also describes use of said novel substituted derivatives of steroids for treatment, especially their use in treating or preventing steroid hormone dependent diseases or disorders, such as those for which inhibition of the 17β-HSD1 and/or STS is necessary and/or for which reduction of concentration of endogenic 17β-oestradiol is necessary.
EFFECT: more effective treatment.
35 cl, 164 ex, 19 tbl
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| PYRAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
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