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2 665 133

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IPC

G01N33/48(2006-01-01)

A61K31/282(2006-01-01)

A61K31/704(2006-01-01)

A61K31/4375(2006-01-01)

A61K31/7068(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2017112674, 2017-04-12

(24)

Start date

2017-04-12

(22)

Actual filing date

2017-04-12

(45)

Published

2018-08-28

(72)

Inventor

Rodionov Evgenij OlegovichEfteev Leonid AleksandrovichMiller Sergej ViktorovichTuzikov Sergej AleksandrovichLitvyakov Nikolaj VasilevichTsyganov Matvej MikhajlovichYumov Evgenij Leonidovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Natsionalnyj Issledovatelskij Meditsinskij Tsentr" Rossijskoj Akademii Nauk Nimts")

METHOD OF PERSONALIZED COMBINED TREATMENT OF NON-CELL LUNG CANCER 1B-111 STAGE ON THE BASIS OF ESTIMATION OF THE LEVELS OF EXPRESSION OF MONORESISTENCE GENES Russian patent published in 2018 - IPC G01N33/48 A61K31/282 A61K31/704 A61K31/4375 A61K31/7068 A61P35/00

Abstract RU 2665133 C1

FIELD: medicine.

SUBSTANCE: present invention relates to medicine, namely, to oncology, and relates to combined treatment of non-small cell lung cancer IB-III stage. Treatment is carried out by introduction of carboplatin in combination with one of the following cytotoxic drugs: gemcitobin, irinotecan, vinorelbine doxorubicin and paclitaxel. Choice of a specific cytotoxic is carried out taking into account the level of expression of monoresistant genes RRM1, TYMS, ABCC5, BRCA1, ERCC1, TOP1, TOP2a, TUBB3 in certain ratios.

EFFECT: this provides higher effectiveness of treatment and reduction in side effects due to personified approach to the prescription of chemotherapy.

1 cl, 5 ex

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RU 2 665 133 C1

Authors

Rodionov Evgenij Olegovich

Efteev Leonid Aleksandrovich

Miller Sergej Viktorovich

Tuzikov Sergej Aleksandrovich

Litvyakov Nikolaj Vasilevich

Tsyganov Matvej Mikhajlovich

Yumov Evgenij Leonidovich

Dates

2018-08-28—Published

2017-04-12—Filed