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2 773 100

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(51)

IPC

A61K31/282(2006-01-01)

A61K31/337(2006-01-01)

A61K31/4745(2006-01-01)

A61K31/513(2006-01-01)

A61K31/519(2006-01-01)

A61K31/7068(2006-01-01)

A61P35/00(2006-01-01)

G01N33/58(2006-01-01)

(21) (22)

Application

2021113053, 2021-05-04

(24)

Start date

2021-05-04

(22)

Actual filing date

2021-05-04

(45)

Published

2022-05-30

(72)

Inventor

Markovich Vitalij AleksandrovichTuzikov Sergej AleksandrovichPopova Natalya OlegovnaRodionov Evgenij OlegovichMiller Sergej ViktorovichLevonyan Levon VladimirovichTsydenova Irina AleksandrovnaIbragimova Marina KonstantinovnaTsyganov Matvej MikhajlovichLitvyakov Nikolaj Vasilevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Natsionalnyj Issledovatelskij Meditsinskij Tsentr Rossijskoj Akademii Nauk" Nimts)

METHOD FOR COMBINED TREATMENT OF RESECTABLE LOCALLY ADVANCED GASTRIC CANCER WITH PERITONEAL CARCINOMATOSIS APPLYING PERSONALISED SYSTEMIC AND INTRAPERITONEAL CHEMOTHERAPY Russian patent published in 2022 - IPC A61K31/282 A61K31/337 A61K31/4745 A61K31/513 A61K31/519 A61K31/7068 A61P35/00 G01N33/58

Abstract RU 2773100 C1

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, in particular, to oncology. Proposed is a method for combined treatment of resectable locally advanced gastric cancer with peritoneal carcinomatosis. Surgical treatment is performed to the extent of palliative gastrectomy with peritonectomy and installing a peritoneal port system for postoperative intraperitoneal chemotherapy. Molecular genetic studies of tissues of tumour fragments and metastases are conducted by quantitative real-time PCR. The expression levels of the chemosensitivity genes RRM1, TOP1, TUBB3, TYMS, BRCA1, ERCC1, and ABCC5 are determined. 2 to 3 weeks after surgical treatment, if the condition of the patient is satisfactory, personalised post-operative systemic and intraperitoneal chemotherapy is performed until the toxicity is intolerable or the disease progresses.

EFFECT: invention improves the results of combined treatment of patients with locally advanced gastric cancer with peritoneal carcinomatosis.

1 cl, 1 dwg, 2 tbl, 5 ex

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RU 2 773 100 C1

Authors

Markovich Vitalij Aleksandrovich

Tuzikov Sergej Aleksandrovich

Popova Natalya Olegovna

Rodionov Evgenij Olegovich

Miller Sergej Viktorovich

Levonyan Levon Vladimirovich

Tsydenova Irina Aleksandrovna

Ibragimova Marina Konstantinovna

Tsyganov Matvej Mikhajlovich

Litvyakov Nikolaj Vasilevich

Dates

2022-05-30—Published

2021-05-04—Filed