HEPATITIS VIRUS PENETRATION INHIBITOR AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HEPATITIS Russian patent published in 2018 - IPC C07D285/32 A61K31/5415 A61P31/20 

Abstract RU 2662161 C1

FIELD: pharmaceuticals.

SUBSTANCE: present invention relates to the use of 1,1-dioxo-1,4-dihydro-2H-benzo[1,2,4]thiadiazine-3-one of general formula 1 as inhibitors of the penetration of hepatitis D virus (HDV). Inhibitors block the NTCP receptor of hepatocyte, the activity of which promotes the development of hepatitis D. In general formula 1

, Ar1 and Ar2 are optionally identical phenyls optionally substituted with one, two or three substituents selected from C1-C4alkyl, methoxyl, halogen and carbonitrile.

EFFECT: invention also relates to a novel compound 1_7 selected from the group of compounds of general formula 1, which additionally has the properties of an inhibitor of hepatitis B virus (HBV).

8 cl, 5 ex

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RU 2 662 161 C1

Authors

Aleksandr Vasilevich Ivashchenko

Andrej Aleksandrovich Ivashchenko

Nikolaj Filippovich Savchuk

Boris Rogovoj

Vadim Vasilevich Bychko

Aleksandr Khvat

Dates

2018-07-24Published

2017-08-11Filed