FIELD: pharmaceuticals.
SUBSTANCE: present invention relates to the use of 1,1-dioxo-1,4-dihydro-2H-benzo[1,2,4]thiadiazine-3-one of general formula 1 as inhibitors of the penetration of hepatitis D virus (HDV). Inhibitors block the NTCP receptor of hepatocyte, the activity of which promotes the development of hepatitis D. In general formula 1
         ,
,  Ar1 and Ar2 are optionally identical phenyls optionally substituted with one, two or three substituents selected from C1-C4alkyl, methoxyl, halogen and carbonitrile.
 Ar1 and Ar2 are optionally identical phenyls optionally substituted with one, two or three substituents selected from C1-C4alkyl, methoxyl, halogen and carbonitrile.
EFFECT: invention also relates to a novel compound 1_7 selected from the group of compounds of general formula 1, which additionally has the properties of an inhibitor of hepatitis B virus (HBV).
8 cl, 5 ex
| Title | Year | Author | Number | 
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 | RU2647576C1 | 
| NUCLEOTIDES INCLUDING N-[(S)-1-CYCLOBUTOXYCARBONYL]PHOSPHORAMIDATE FRAGMENT, THEIR ANALOGS AND THEIR APPLICATION | 2017 | 
 | RU2659388C1 | 
| COMBINED DRUG FOR VIRAL INFECTION THERAPY | 2017 | 
 | RU2662160C9 | 
| HEPATITIS B VIRUS (HBV) INHIBITOR, WHICH IS A DERIVATIVE OF N-{3-[6-(DIALKYLAMINO)PYRIDAZINE-3-YL]PHENYL}ARYL SULPHONAMIDE DERIVATIVES AND DERIVATIVES OF N-{4-[6-(DIALKYLAMINO)PYRIDAZINE-3-YL]PHENYL}ARYL SULPHONAMIDE | 2019 | 
 | RU2738848C1 | 
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 | RU2731385C1 | 
Authors
Dates
2018-07-24—Published
2017-08-11—Filed