USE OF NK-1 RECEPTOR ANTAGONIST SERLOPITANT IN PRURITUS Russian patent published in 2018 - IPC A61K31/403 A61P17/04 A61P25/20 

Abstract RU 2666219 C2

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and concerns the treatment of pruritus in a patient who needs such treatment. This treatment comprises the step of administering to the patient a therapeutically effective amount of 3-[(3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]cyclopent-2-en-1-one (serlopitant) or a pharmaceutically acceptable salt, solvate or polymorph thereof. Method for administering a serlopitant to a patient is also provided.

EFFECT: group of the invention provides treatment of pruritus of different genesis in a patient, while the developed scheme of administration of the drug provides a prolonged antipruritic effect.

34 cl, 4 dwg, 7 tbl, 6 ex

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RU 2 666 219 C2

Authors

Zhang Xiaoming

Schnipper Edward F.

Perlman Andrew J.

Larrick James W.

Dates

2018-09-06Published

2014-06-24Filed