FIELD: pharmacology.
SUBSTANCE: use of paralytic shellfish poison (PSP) for topical treatment of pruritus in a human or other mammal, wherein PSP is a saxitoxin or tricyclic 3,4-propinhydropurine represented by the following formula
(I),
where R1 and R5 are independently selected from the group consisting of -H and -OH; R2 and R3 are independently selected from the group consisting of -H, -OSO3- and -SO3; and R4 is selected from the group consisting of -H, -OH, -OC(=O)NH2, -OC(=O)NHSO3- and -OC(=O)CH3, or where PSP is the salt of a saxitoxin or tricyclic 3,4-propinhydropurine. Pharmaceutical composition for topical treatment of pruritus in a human or other mammal. A method for topical treatment of pruritus in a human or other mammal.
EFFECT: group can effectively treat pruritus in a human or other mammals.
22 cl, 1 dwg, 2 tbl
