METHOD OF TREATMENT OF ATHLETE'S FOOT WITH ONYCHOMYCOSIS IN PATIENTS WITH COEXISTING INTESTINE DYSBACTERIOSIS Russian patent published in 2018 - IPC A61K35/38 A61K31/495 A61K31/4196 A61P31/10 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is intended for the treatment of onychomycosis. Determine the content of stool bifidobacteria, lactobacillus, typical escherichia, the presence of PPF, carry out a gas-liquid chromatographic study of stool, determine the concentration of acetic, propionic and butyric acids. With acetic acid values below 0.634 mg/g, propionic and butyric acids above 0.189 mg/g and 0.176 mg/g, respectively, as well as the meaning of the content of bifidobacteria, lactobacillus, typical escherichia, conditionally pathogenic flora 10⁷ CFU/g or less, 10⁵ CFU/g or less, 10⁵ CFU/g or less, 10⁴ CFU/g and more, respectively, predict an increase in the severity of intestinal dysbiosis. Enter Epterosan in a dose of 300 mg 3 times a day for 2–3 months with the use of a systemic antifungal drug itraconazole for 2-3 rounds of therapy, then in a dose of 300 mg 2 times a day until the end of antifungal therapy with itraconazole for more than 3 rounds of therapy.

EFFECT: method ensures the recovery of normal intestinal microflora, significant anti-inflammatory effect, shortened treatment time and achieved remission.

1 cl, 3 tbl, 3 ex