FIELD: pharmaceutics.
SUBSTANCE: invention relates to a compound of formula (I)
in which R1 is methyl or ethyl and R2 is (C2-3)alkyl substituted with a hydroxy group; or a pharmaceutically acceptable salt thereof. Invention also relates to a compound comprising 1-[4-[5-[5-amino-6-(5-t-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1,2,4-triazol-3-yl]-1-piperidyl]-3-hydroxypropan-1-one, to combination suitable for use in the treatment of PI3K-α or PI3K-δ, to pharmaceutical composition, to a method for selecting a patient for treating cancer, and to a method of treating a patient suffering from cancer.
EFFECT: new compounds possessing the properties of a kinase inhibitor PI3K-α or PI3K-δ, which can be useful in the treatment of cancer.
17 cl, 13 dwg, 9 tbl, 11 ex
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