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2 790 228

(13)

(51)

IPC

C07D309/10(2006-01-01)

C07H7/04(2006-01-01)

A61K31/7034(2006-01-01)

A61P1/00(2006-01-01)

A61P13/02(2006-01-01)

A61P29/00(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2020143342, 2019-07-08

(24)

Start date

2019-07-08

(22)

Actual filing date

2019-07-08

(45)

Published

2023-02-15

(72)

Inventor

Bishop, Michael JosephColandrea, Vincent J.Li, YuehuStewart, Eugene L.Strambeanu, IuliaWiddowson, Katherine LouisaJanetka, James WalterMcgrane, Laurel Kathryn

(73)

Holder

Glaxosmithkline Intellectual Property Development LimitedFimbrion Therapeutics, Inc.

C-MANNOSIDE COMPOUNDS USED FOR TREATMENT OF URINARY TRACT INFECTIONS Russian patent published in 2023 - IPC C07D309/10 C07H7/04 A61K31/7034 A61P1/00 A61P13/02 A61P29/00 A61P31/04

Abstract RU 2790228 C2

FIELD: medicine.

SUBSTANCE: invention relates to new compounds of C-mannoside of the formula I or their pharmaceutically acceptable salts, which have inhibitory activity relatively to FimH. In the formula I, R₁ is CH₃ or CF₃; R₂ is H; R₃ is F; R₄ is CH₃, Cl, Br, vinyl, CF₃, F, or H; R₅ is F or H; and R₆ is H. The invention also relates to a pharmaceutical composition, including for local and oral administration, containing a compound of the formula I, a method for inhibition of FimH function, and a method for treatment of FimH-mediated disease.

EFFECT: obtainment of a compound for the treatment of urinary tract infections.

28 cl, 2 tbl, 110 ex

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RU 2 790 228 C2

Authors

Bishop, Michael Joseph

Colandrea, Vincent J.

Li, Yuehu

Stewart, Eugene L.

Strambeanu, Iulia

Widdowson, Katherine Louisa

Janetka, James Walter

Mcgrane, Laurel Kathryn

Dates

2023-02-15—Published

2019-07-08—Filed