NOVEL CYCLOHEXANE DERIVATIVE, PRODRUG AND SALT THEREOF AND DIABETES THERAPEUTIC AGENT CONTAINING SAID COMPOUNDS Russian patent published in 2010 - IPC C07C43/23 C07C43/253 C07C49/84 C07C39/17 C07C35/21 C07C69/94 C07C323/20 C07C317/22 C07C255/54 C07C217/56 C07C65/26 C07C235/42 C07D333/56 C07D213/65 C07D307/80 C07D231/12 C07D317/54 C07D333/16 C07D209/12 A61K31/85 A61K31/10 A61K31/277 A61K31/137 A61K31/166 A61K31/235 A61K31/415 A61K31/381 A61K31/4409 A61K31/192 A61K31/343 A61K31/122 A61K31/05 A61P3/04 A61P3/10 

Abstract RU 2394015 C2

FIELD: chemistry; pharmaceutics.

SUBSTANCE: present invention relates to novel cyclohexane derivatives of formula (I) or their pharmaceutically acceptable salts having inhibitory effect on Na+-glucose cotranspoter (SGLT2), as well as to pharmaceutical compositions based on the said compounds and their use in preventing or treating diabetes, diabetic complications caused by hyperglycaemia or obesity. , where A is -O-; n is an equal to 0 or 1; R6 and R7 each independently represents a hydrogen atom or a C1-C6alkyl group, m is an integer selected from 1-3; Q is selected from Q1 - Q5, given in formula 2.

EFFECT: obtaining novel cyclohexane derivatives or their pharmaceutically acceptable salts and preparation of a pharmaceutical composition based on the said compounds.

15 cl, 19 dwg, 11 tbl, 86 ex

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RU 2 394 015 C2

Authors

Matsuoka Khirokharu

Sato Tsutomu

Nisimoto Masakhiro

Simma Nobuo

Dates

2010-07-10Published

2005-07-26Filed