NEW GLUCITOL DERIVATIVE, PRODRUG AND SALT AND THERAPEUTIC AGENT CONTAINING THEM FOR DIABETES TREATMENT Russian patent published in 2010 - IPC C07D409/10 A61K31/381 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention concerns a new glucitol derivative of formula (I): wherein m represents an integer chosen from 1-3; each R¹, R², R³ and R⁴ are independently choose from hydrogen atom and benzyl groups; Ar¹ represents a naphthyl group which can be substituted by one or more substitutes chosen from the group, consisting of C₁-C₆alkyl group or halogen atom; A represents 5-7-members aromatic heterocyclic group containing one or more heteroatoms independently chosen from oxygen atom and sulphur atom which can form a condensed cycle with an aromatic carbocycle or an aromatic heterocycle where A can be substituted by one or more R_b provided when A is a benzocondensed cycle containing two or more rings, the group -(CH₂)_m- is connected with a heterocycle in A; Each R_b is independently chosen from C₁-C₆alkyl group, halogen atom and C₁-C₆-alkoxy group; or to their pharmaceutically acceptable salts. These compounds are used as a Na⁺ cotransport inhibitor and exhibits ability to reduce blood sugar level.

EFFECT: invention covers a pharmaceutical composition based on these compounds and to the method for treatment and prevention of such diseases associated with hyperglycemia, as diabetes, diabetes complications and obesity.

12 cl, 4 tbl, 5 ex