PHARMACEUTICAL COMPOSITION FOR EXTERNAL USE CONTAINING A SALT OF DEXKETOPROFEN, AND A PROCESS FOR ITS PREPARATION Russian patent published in 2018 - IPC A61K31/19 A61K9/06 A61K47/20 A61K47/10 A61P19/02 

FIELD: medicine; chemical and pharmaceutical industry.

SUBSTANCE: invention relates to medicine and chemical-pharmaceutical industry, namely to pharmaceutical composition for external use, which has an analgesic and anti-inflammatory effect, as well as a method for its preparation. Pharmaceutical composition contains dexketoprofen trometamol and target additives: dimethylsulfoxide, ethanol (96 %), carbomer, neutralizer, flavor and purified water. Composition preferably contains as a carbomer a hydrophobically modified cross-linked polyacrylate Carbopol carbomer^® Ultrez 21 Polymer, as a neutralizer, tetrahydroxypropylethylenediamine (Neutrol^® TE), and as a flavoring – lavender oil. Claimed drug has a high analgesic activity and prolonged effective anti-inflammatory action.

EFFECT: implementation of the invention allows to obtain a homogeneous pharmaceutical composition in which dexketoprofen is very stable and does not precipitate upon contact of preparation with air.

7 cl, 4 ex, 10 tbl